Cytokines from natural killer or t cells

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/52 (2006.01) A61K 38/19 (2006.01) A61K 39/39 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C07K 16/42 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2176114

Cell-free preparations of a cytokine produced by natural killer (NK) cells activated with interleukin 2 (IL-2) or produced by CD4+ T cells activated with anti-CD3 monoclonal antibody are described. This cytokine induces antibody secretion by activated B cells. Methods for producing the cell-free supernatants containing the cytokine are also described.

Préparations d'une cytokine, exempte de cellules, produite soit par des cellules tuteuses naturelles (NK) activées par de l'interleukine 2 (IL-2), soit par des lymphocytes T à CD4?+¿ activés par l'anticorps monoclonal anti-CD3. Ladite cytokine induit des sécrétions d'anticorps par les lymphocytes B activés. L'invention concerne également des procédés de production de surnageants exempts de cellules contenant ladtie cytokine.

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