Cytokines that bind the cell surface receptor hek

C - Chemistry – Metallurgy – 12 – N

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C12N 15/19 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2169851

Hek ligand (hek-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing hek-L polypeptides. The hek-L polypeptides bind to a cell surface receptor (hek) that is a member of the receptor tyrosine kinase family. Hek is expressed on cells that include certain tumor cell lines. The hek-L polypeptides also bind a distinct receptor tyrosine kinase known elk.

Polypeptides ligands du HEK (hek-L) ainsi que séquences, vecteurs et cellules hôtes transformées d'ADN servant à l'obtention de polypeptides hek-L. Lesdits polypeptides se fixent à un récepteur de la surface cellulaire (hek) de la famille des récepteurs tyrosine kinase. Le hek est exprimé par des cellules contenant certaines lignées cellulaires tumorales. Les polypeptides hek-L se fixent également à un récepteur de tyrosine kinase distinct, dit elk.

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