Cytomodulating conjugates of members of specific binding pairs

Details Cytomodulating conjugates of members of specific binding pairs Cytomodulating conjugates of members of specific binding pairs

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/385 (2006.01) A61K 39/44 (2006.01)

Patent

CA 2218737

Novel conjugates are provided comprising a moiety capable of specifically binding to a target cell joined to a selective moiety for binding to an endogenous effector agent, capable of causing cell inactivation or cytotoxicity. Example of conjugates are a ligand for a surface membrane protein, e.g. IL-2 receptor, joined to an .alpha.-galactosyl epitope, or a polysaccharide A or B antigen. The conjugates may be used to specifically destroy cells associated with a pathogenic condition.

Nouveaux conjugués comprenant une fraction capable de se lier spécifiquement à une cellule cible unie à une fraction sélective quant à sa liaison avec un agent effecteur endogène capable de déclancher une inactivation des cellules ou une cytotoxicité. Au nombre de tels conjugués, on peut citer un liant pour une protéïne de membrane superficielle, par exemple le récepteur d'IL-2, uni à un épitope .alpha.-galactocyle ou un antigène A ou B polysaccharide. Ces conjugués peuvent être utilisés pour détruire spécifiquement des cellules associées à un état pathogène.

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