Cytopathic viruses for therapy and prophylaxis of neoplasia

Details Cytopathic viruses for therapy and prophylaxis of neoplasia Cytopathic viruses for therapy and prophylaxis of neoplasia

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 35/76 (2006.01) C07K 14/075 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2273825

Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

L'invention concerne des procédés et des compositions permettant de traiter des pathologies néoplastiques par thérapie à base virale. Des virus mutants dépourvus de protéines virales qui lient et/ou inactivent p53 ou RB sont administrés à un patient présentant un néoplasme contenant des cellules exemptes de la fonction p53 et/ou RB. Le virus mutant est capable de produire sensiblement un phénotype de réplication dans des cellules néoplastiques, mais est sensiblement incapable de produire un phénotype de réplication dans des cellules non réplicantes et non néoplastiques présentant notamment la fonction p53 et/ou RB normale. La génération préférentielle du phénotype de réplication dans des cellules néoplastiques entraîne la destruction préférentielle des cellules néoplastiques, directement ou par expression d'un gène cytotoxique dans les cellules exprimant un phénotype de réplication viral.

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