Cytopathic viruses for therapy and prophylaxis of neoplasia

Details Cytopathic viruses for therapy and prophylaxis of neoplasia Cytopathic viruses for therapy and prophylaxis of neoplasia

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 35/76 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2152941

Methods and compositions for treating neoplastic conditions by viral-based therapy are provided. Mutant virus lacking viral proteins which bind and/or inactivate p53 or RB are administered to a patient having a neoplasm which comprises cells lacking p53 and/or RB function. The mutant virus is able to substantially produce a replication phenotype in neoplastic cells but is substantially unable to produce a replication phenotype in non-replicating, non-neoplastic cells having essentially normal p53 and/or RB function. The preferential generation of replication phenotype in neoplastic cells results in a preferential killing of the neoplastic cells, either directly or by expression of a cytotoxic gene in cells expressing a viral replication phenotype.

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