Cytoplasmic expression of antibodies, antibody fragments and...

Details Cytoplasmic expression of antibodies, antibody fragments and... Cytoplasmic expression of antibodies, antibody fragments and...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 9/24 (2006.01) C12N 15/00 (2006.01) C12N 15/13 (2006.01) C12N 15/70 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2173822

The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli. In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.

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