Cytoplasmic modulators of integrin regulation/signaling

Details Cytoplasmic modulators of integrin regulation/signaling Cytoplasmic modulators of integrin regulation/signaling

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C12N 5/16 (2006.01) C12N 5/18 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2224571

The present invention provides purified and isolated polynucleotides encoding IRP polypeptides which regulate .beta.2 and .beta.7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes.

L'invention concerne des polynucléotides purifiés et isolés codant pour des polypeptides IRP (protéines de régulation de l'intégrine), qui régulent les intégrines .beta.¿2? et .beta.¿7? et qui devraient participer aux voies de signalisation et/ou de recyclage de l'intégrine. Elle concerne également des procédés permettant d'identifier des modulateurs des activités des IRP et des procédés permettant d'identifier d'autres protéines interagissant avec les polypeptides IRP dans les voies de signalisation. Les modulateurs des interactions des IRP sont considérés comme utiles, par exemple, pour la surveillance et le traitement des processus inflammatoires impliquant les leucocytes.

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