C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/732 (2006.01) C07C 219/08 (2006.01) C07C 229/16 (2006.01) C07C 233/38 (2006.01) C07C 235/28 (2006.01) C07C 309/14 (2006.01) C07C 309/15 (2006.01) C07F 9/38 (2006.01)
Patent
CA 2252084
The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. A composition of the formula: (see formula I) wherein A comprise H, OH, a sugar moiety, an ether, an ester, an amide, NH2, or an acid or salt thereof, B is selected from the group consisting of N, NR, P, P=O, CH and CR, wherein R is an alkyl chain of 1 to 6 carbons and the chain may be functionalized or non--functionalized. C1, C2 and C3 are connecting groups which may be different and are selected from the group consisting of -(CH2)n- and (CH2CH2-O)y wherein n is an integer from 1 to 24, -(CH2)n- may be functionalized or non-functionalized, and y is an integer from 1 to 12, and D1 and D2 are fatty acid chains which may be different and are selected from the group consisting of fatty acid esters including CH3(CH2)n COO, and fatty acid amides of the form CH3(CH2)n CONH, wherein n is an integer from 1 to 32, at least one of the fatty chains is unsaturated at one or more positions, and the fatty chains may be of different lengths and may be unsaturated at different locations. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
L'invention concerne des compositions et des procédés permettant de protéger les cellules contre des lésions dues à la lyse de la membrane, à l'oxydation et/ou à l'invasion par des agents destructeurs. Plus particulièrement, elle concerne des compositions et des procédés permettant de traiter ou d'inhiber préventivement les lésions dont les phospholipases sont les médiatrices, les lésions par oxydation et l'inflammation. Dans un sens très spécifique, l'invention concerne des compositions et des procédés permettant de préparer ces compositions qui inhibent les phospholipases.
Franson Richard C.
Ottenbrite Raphael M.
Finlayson & Singlehurst
Virginia Commonwealth University
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