Cytoprotective derivatives useful in ischemic diseases,...

Details Cytoprotective derivatives useful in ischemic diseases,... Cytoprotective derivatives useful in ischemic diseases,...

C - Chemistry, Metallurgy

07

C

167/237, 167/252

C07C 279/00 (2006.01) A61K 31/415 (2006.01) C07D 233/88 (2006.01)

Patent

CA 1284646

Abstract CYTOPROTECTIVE DERIVATIVES USEFUL IN ISCHEMIC DISEASES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM Compounds of the general formula I Image (I) wherein R1 is hydrogen or methyl; R2 and R3, which are the same or different, represent hydrogen or methyl, or taken together, form the amidine system to which an imidazole or imidazoline ring is bound; R4 is a linear or branched C1-C10 alkyl group; cycloalkyl, aryl, aralkyl or heteroaryl group; R5 is hydrogen or methyl; A is a propylene chain optionally subsituted by one or two methyl groups in one or more of the positions thereof; a chain of formula -HN-CH2-CH2- or of formula -N=CH-CH2-; a 1,4-cyclohexylene group optionally substituted by one or more methyl groups; a 1,4- phenylene group optionally substituted by one or more halogen atoms, alkyl groups or C1-C4 alkoxy group with the proviso that, when R4 is me- thyl or ethyl and R1=R2=R3=R5 are hydrogen, A is different from an unsubstituted propylene chain, are therapeutically useful as antiischemic, cytoprotective and cardioprotective agents.

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