Cytoprotective steroids (ii)

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/565 (2006.01) A61K 31/567 (2006.01) A61K 31/5685 (2006.01) A61K 31/57 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2398706

A method is provided for treating a patient in need of therapy for acute neuronal degeneration due to metabolic compromise of central or peripheral nervous system cells comprising administering to that patient a therapeutically effective amount of a 7.alpha.-hydroxy substituted steroid selected from 7.alpha.-hydroxy-derivatives of estradiols, dehydroepiandrosterones and pregnenolones, and metabolic precursors thereof. Use of such compounds for manufacture of medicaments and neuroprotective compositions are also provided.

L'invention concerne un procédé pour traiter un patient nécessitant un traitement suite à une dégénérescence neuronale aiguë provoquée par une compromission métabolique de cellules des systèmes nerveux central ou périphérique. Le procédé consiste à administrer au patient une quantité thérapeutiquement efficace de stéroïde 7.alpha.-hydroxy substitué sélectionné parmi les dérivés 7.alpha.-hydroxy d'estradiols, les déhydroépiandrostérones et les pregnenolones ainsi que leurs précurseurs métaboliques. L'invention concerne aussi l'utilisation de ces composés dans la fabrication d'une composition à effet médicinal et neuroprotecteur.

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