Cytosine deaminase gene

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/02 (2006.01) C12N 9/78 (2006.01)

Patent

CA 2328596

The present invention relates to a cytosine deaminase (CD) gene optimal for gene or viral directed enzyme prodrug therapy (GDEPT or VDEPT). The invention further relates to recombinant molecules comprising the CD gene and to host cells comprising same. The invention also relates to methods of effecting GDEPT or VDEPT using the CD gene.

La présente invention concerne un gène de cytosine déaminase (CD) optimal en terme de thérapie dirigée, génique ou virale, à base d'un promédicament enzyme (GDEPT ou VDEPT). L'invention concerne aussi des molécules recombinantes comprenant le gène CD, et des cellules hôtes comprenant ce gène. Cette invention concerne aussi des procédés de mise en oeuvre de GDEPT et de VDEPT au moyen du gène CD.

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