Cytosine deaminase negative selection system for gene...

Details Cytosine deaminase negative selection system for gene... Cytosine deaminase negative selection system for gene...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61K 39/00 (2006.01) A61K 39/108 (2006.01) A61K 48/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 9/78 (2006.01) C12N 15/55 (2006.01) C12N 15/867 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2112395

The present invention relates to a system comprising a modified bacterial gene for cytosine deaminase that has been engineered into a eukaryotic expression vector and the expression of the gene by murine fibroblasts. The present invention further relates to methods, gene therapies and vaccines that employ the negative selectable marker, cytosine deaminase, which has the ability to produce a toxic antimetabolite 5-fluorouracil from 5- fluorocytosine.

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