C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/06 (2006.01) A61K 31/22 (2006.01) A61K 31/381 (2006.01) A61P 35/00 (2006.01) C07D 333/24 (2006.01)
Patent
CA 2323414
2(R or S)-[2R-(S-Hydroxy-hydroxycarbamoyl-methyl)-4-methyl-pentanoylamine]-2- phenyl-ethanoic acid cyclopentyl ester, 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2- phenylethanoic acid isopropyl ester, 2(R or S)-[2R-(S-Hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]}-3- phenylethanoic acid cyclopentyl ester; 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(4- methoxyphenyl)ethanoic acid cyclopentyl ester; 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(thien-2- yl)ethanoic acid cyclopentyl ester, and 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(thien-3-y1)ethanoic acid cyclopentyl ester are cytostatic agents.
L'ester cyclopentylique d'acide 2(R ou S)-[2R-(S-Hydroxy-hydroxycarbamoyl-méthyl)-4-méthyl-pentanoylamine]-2-phényl-éthanoïque; l'ester isopropylique d'acide 2(R ou S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-énoylamino)-2-phényléthanoïque; l'ester cyclopentylique d'acide 2(R ou S)-[2R-(S-Hydroxycarbamoyl-méthoxy-méthyl)-4-méthyl-pentanoylamino]-3-phényléthanoïque; l'ester cyclopentylique d'acide 2(R ou S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-énoylamino)-2-(4-méthoxyphényl)éthanoïque; l'ester cyclopentlylique d'acide 2(R ou S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-énoylamino)-2-(thien-2-yl)éthanoïque; et l'ester cyclopentylique d'acide 2(R ou S)-(3S-hydroxycarbamoyl-2R-isobutyl-hex-5-énoylamino)-2-(thien-3-yl)éthanoïque sont des cytostatiques.
Ayscough Andrew Paul
Drummond Alan Hastings
Huxley Philip
Pearson Lindsey Ann
British Biotech Pharmaceuticals Limited
Gowling Lafleur Henderson Llp
Vernalis (r&d) Limited
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