C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/351
C07D 317/10 (2006.01) C07D 317/12 (2006.01) C07D 317/20 (2006.01) C07D 317/26 (2006.01) C07D 493/04 (2006.01)
Patent
CA 1142948
ABSTRACT OF THE DISCLOSURE The invention provides a process for the production of novel cyclic acetals of the general formulae: Image , Image and Image wherein R1 is Image , Image , Image or Image wherein R2 is hydrogen, alkyl, aryl or R1, wherein R3 through R10 are hydrogen, alkyl or aryl, wherein R5 and R6 together may form =O, wherein X is hydrogen, alkyl, cycloalkyl, aryl, hydroxy- aryl or arylalkyl, or wherein R8 is Image are described. Said compounds are prepared by mixing approximately equimolar amounts of the appropriate aldehyde or ketone, and enediol compound, and allowing same to react in aqueous solution under a nitrogen atmosphere. Compositions containing these novel cornpounds exhibit cytostatic, hypotensive and analgesic properties and are useful in the treatment of cancer in animals and humans.
329092
Fodor Gabor B.
Szent-Gyorgyi Albert
G. Ronald Bell & Associates
National Foundation For Cancer Research
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