Cytostatic terminally bifunctional sugar alcohols process...

Details Cytostatic terminally bifunctional sugar alcohols process... Cytostatic terminally bifunctional sugar alcohols process...

C - Chemistry, Metallurgy

07

C

260/472, 260/632

C07C 43/13 (2006.01) C07C 69/00 (2006.01) C07D 303/22 (2006.01) C07D 303/28 (2006.01)

Patent

CA 1189525

ABSTRACT OF THE DISCLOSURE The invention relates to novel anticarcinogenic compounds of formula I Image wherein R is halogen R is hydroxy or R1 and R2 together form an oxygen bridge, R3 is methyl, R4 is hydrogen, methyl or acyl, n is 1 or zero, with the provisos, that in case n is 1 the steric positions of -R2, OR3 and -OR4 groups correspond to dulcitol, mannitol or sorbitol configurations independently of their actual meanings, in case n is zero the steric positions of -R and -OR groups correspond to xylitol configuration independently of their actual meanings. The novel compounds can be used as antitumour agents in themselves or formulated as pharmaceutical preparations.

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