Cytotoxic agents

Details Cytotoxic agents Cytotoxic agents

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/00 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C12N 15/09 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2404998

A method of killing a cell that is lacking in effective p53 protein activity, particularly as compared to wild type, is provided characterised in that it comprises delivering to the cell a single stranded DNA including a portion with at least one base, internally located with respect to any 3' and 5' ends of the DNA, that is unbasepaired with another base in a form that is capable of being internalised by the cell.

L'invention concerne un procédé permettant de tuer un cellule ne présentant pas une activité efficace de la protéine p53, notamment par rapport au type sauvage, lequel procédé consiste à introduire dans la cellule un ADN monocaténaire comprenant une portion avec au moins une base, située à l'intérieur par rapport aux extrémités 3' et 5' de l'ADN, non assemblée à une autre base, sous une forme permettant d'être assimilée par la cellule.

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