Cytotoxic agents comprising maytansinoids and their...

Details Cytotoxic agents comprising maytansinoids and their... Cytotoxic agents comprising maytansinoids and their...

C - Chemistry, Metallurgy

07

D

C07D 498/14 (2006.01) A61K 31/365 (2006.01) A61K 31/535 (2006.01) A61K 31/537 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 7/04 (2006.01)

Patent

CA 2026147

8~A cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. A therapeutic agent for killing selected cell populations comprising: (a) a cytotoxic amount of one or more maytansinoids linked to a cell binding agent, and (b) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting a cell population or tissue suspected of containing cells from said selected cell population with a cytotoxic amount of a cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. An N-methyl-alanine-containing ester of maytansinol or an analogue of maytansinol, said N-methyl- alanine-containing ester comprising a linking group capable of linking an N-methyl-alanine-containing maytansinoid ester to a chemical moiety. N-methyl-cysteine-containing ester of maytansinol or an analogue of maytansinol.

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