Cytotoxic agents comprising new c-2 modified taxanes

Details Cytotoxic agents comprising new c-2 modified taxanes Cytotoxic agents comprising new c-2 modified taxanes

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2614574

The present invention relates to novel cytotoxic agents and their therapeutic use. More specifically, the invention relates to novel cytotoxic agents comprising taxanes and their therapeutic use. These novel cytotoxic agents have therapeutic use as a result of delivering the taxanes to a specific cell population in a targeted fashion by chemically linking the taxane to a cell binding agent.

L'invention concerne de nouveaux agents cytotoxiques et leur utilisation thérapeutique. De manière plus spécifique, l'invention concerne de nouveaux agents cytotoxiques comprenant des taxanes et leur utilisation thérapeutique. Les nouveaux agents cytotoxiques présentent une utilisation thérapeutique obtenue à partir de l'administration des taxanes à une population de cellules spécifiques de manière ciblée par une liaison chimique du taxane à un agent de liaison de la cellule.

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