C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/5517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2693551
The invention relates to novel tomaymicine derivatives comprising a linker. It also relates to the conjugate molecules that comprise one or more of said tomaymicine derivatives covalently linked to a cell binding agent through a linking group that is present on the linker of the tomaymycin derivative. It also relates to the preparation of the tomaymicine derivatives and of the conjugate molecules.
L'invention concerne de nouveaux dérivés de la tomaymycine comprenant un lieur. L'invention concerne également des molécules conjuguées qui comprennent un ou plusieurs desdits dérivés de la tomaymycine liés de manière covalente à un agent de liaison cellulaire par un groupe liant qui est présent sur le lieur du dérivé de la tomaymycine. L'invention concerne également la préparation des dérivés de la tomaymycine et des molécules conjuguées.
Bouchard Herve
Chari Ravi V.j.
Commercon Alain
Deng Yonghong
Gauzy Laurence
Robic
Sanofi-Aventis
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