Cytotoxic agents comprising taxanes and their therapeutic use

Details Cytotoxic agents comprising taxanes and their therapeutic use Cytotoxic agents comprising taxanes and their therapeutic use

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2388063

A cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. Novel sulfur-containing taxanes.

Cette invention se rapporte à un agent cytotoxique comprenant un ou plusieurs taxanes liés à un agent de fixation des cellules; à une composition thérapeutique servant à détruire des populations de cellules choisies et comprenant à cet effet: (A) une quantité cytotoxique d'un ou de plusieurs taxanes liés par covalence à un agent de fixation des cellules par un groupe de liaison, et (B) un véhicule, un diluant ou un excipient acceptable sur le plan pharmaceutique; à un procédé de destruction de populations de cellules choisies consistant à mettre des cellules cibles ou des tissus contenant des cellules en contact avec une quantité efficace d'un agent cytotoxique comprenant un ou plusieurs taxanes liés à un agent de fixation des cellules. Cette invention concerne également de nouveaux taxanes contenant du soufre.

Affiliated with

Also associated with

Rating

Cytotoxic agents comprising taxanes and their therapeutic use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cytotoxic agents comprising taxanes and their therapeutic use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cytotoxic agents comprising taxanes and their therapeutic use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2031028