Cytotoxic anti-lag-3 monoclonal antibody and its use in the...

Details Cytotoxic anti-lag-3 monoclonal antibody and its use in the... Cytotoxic anti-lag-3 monoclonal antibody and its use in the...

A - Human Necessities

61

K

A61K 39/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2685584

The present invention concerns a molecule binding to LAG-3 protein and causing depletion of LAG-3' activated T cells particularly said molecule is a cytotoxic anti-LAG-3 monoclonal antibody or fragment thereof. It also concerns a method of treating or preventing organ transplant rejection or autoimmune diseases in a mammal comprising administering to said mammal a therapeutically effective amount of said antibody.

La présente invention porte sur une molécule se liant à la protéine LAG-3 et provoquant un épuisement de lymphocytes T activés par LAG-3'. En particulier, ladite molécule est un anticorps monoclonal anti-LAG-3 cytotoxique ou un fragment de celui-ci. L'invention porte également sur un procédé de traitement ou de prévention d'un rejet de greffon d'organe ou de maladies auto-immunes dans un mammifère, comprenant l'administration audit mammifère d'une quantité thérapeutiquement efficace dudit anticorps.

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