C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 49/733 (2006.01) A61K 31/12 (2006.01) A61K 31/22 (2006.01) A61K 31/27 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 45/64 (2006.01) C07C 45/67 (2006.01) C07C 69/013 (2006.01) C07C 69/28 (2006.01) C07C 69/96 (2006.01) C07C 271/34 (2006.01) C07D 213/75 (2006.01) C07D 241/44 (2006.01) C07D 303/32 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2081007
CT-2057B ABSTRACT The present invention relates to a novel and efficient process for the preparation of 8-hydroxy- bicyclo[7.3.1]tridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic antitumor agents having said bicyclic ring system. The present invention also provides a method for treating mammalian malignant tumors by administering to an animal in need of such treatment an antitumor effective amount of a compound of the present invention.
Kadow John F.
Wittman Mark D.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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