Cytotoxic bicyclo¬7.3.1| tridec-4-ene-2,6-diyne compounds...

Details Cytotoxic bicyclo¬7.3.1| tridec-4-ene-2,6-diyne compounds... Cytotoxic bicyclo¬7.3.1| tridec-4-ene-2,6-diyne compounds...

C - Chemistry, Metallurgy

07

F

167/280, 260/429

C07F 15/06 (2006.01) A61K 31/12 (2006.01) C07C 45/67 (2006.01) C07C 49/733 (2006.01) C07C 49/737 (2006.01) C07C 323/22 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2040855

ABSTRACT The present invention relates to a novel and efficient process for the preparation of 8-hydroxy-bicyclo[7.3.1]- tridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic agents having said bicyclic ring system. The present invention also provides a method for treating animal malignant tumors by administering to an animal in need of such treatment an antitumor effective amount of a compound having the formula, Image

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