Cytotoxic compounds and conjugates comprising duocarmycins...

Details Cytotoxic compounds and conjugates comprising duocarmycins... Cytotoxic compounds and conjugates comprising duocarmycins...

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2603860

The present disclosure provides drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-cleavable substrate conjugates, and to methods of treatment using them.

La présente invention concerne des conjugués à substrats clivables de médicament qui constituent des cytotoxines puissantes. Ladite invention a trait à des compositions contenant lesdits conjugués et à des méthodes de traitement les utilisant.

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