Cytotoxic compounds: derivatives of the pyrido¬2,3,4-kl|...

Details Cytotoxic compounds: derivatives of the pyrido¬2,3,4-kl|... Cytotoxic compounds: derivatives of the pyrido¬2,3,4-kl|...

C - Chemistry, Metallurgy

07

D

C07D 471/16 (2006.01) A61K 31/44 (2006.01) C07D 471/06 (2006.01)

Patent

CA 2287862

Compounds of formula (I), wherein X is selected from the group consisting of O, and NR3, where R3 represents a lower alkyl group; Y is selected from the group consisting of CH and N; R1 and R2 are independently selected from the group consisting of NH2, NHR4 and NR52, where R4 and R5 each represent a lower alkyl group, or R1 and R2 together represent a cycle selected from (a), (b) and (c), wherein R6, R7 and R8 are independently selected from the group consisting of hydrogen atoms, lower alkyl groups, hydroxy groups and lower alkoxy groups; and Z is selected from the group consisting of O.

L'invention concerne des composés de formule (I) (I) dans laquelle: X est choisi dans le groupe composé de O et NR?3¿, R?3¿ représentant un groupe alkyle inférieur; Y est choisi dans le groupe composé de CH et N; R?1¿ et R?2¿ sont choisis indépendamment dans le groupe composé de NH¿2?, NHR?4¿, et NR?5¿¿2?, R?4¿ et R?5¿ représentant chacun un groupe alkyle inférieur, ou R?1¿ et R?2¿ représentant ensemble un cycle choisi parmi a), b), et c): dans lesquels R?6¿, R?7¿, et R?8¿ sont choisis indépendamment dans le groupe composé des atomes d'hydrogène, des groupes alkyles inférieurs, des groupes hydroxy, et des groupes alkoxy inférieurs; et Z est choisi dans le groupe composé de O.

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