Cytotoxic heteromeric protein combinatorial libraries

Details Cytotoxic heteromeric protein combinatorial libraries Cytotoxic heteromeric protein combinatorial libraries

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A61K 31/70 (2006.01) A61K 39/02 (2006.01) C07K 14/25 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2319720

A method is provided for constructing, identifying and using new therapeutic or diagnostic proteins capable of binding to a target cell. The new proteins are derived by mutating a binding subunit of a wild type heteromeric cytotoxic protein to create a library of microorganism clones producing mutant proteins which are then screened for their ability to specifically bind to and kill a target cell.

L'invention concerne un procédé de construction, d'identification et d'utilisation de nouvelles protéines thérapeutiques ou diagnostiques, capables de se fixer à une cellule cible. Lesdites nouvelles protéines sont dérivées par la mutation d'une sous-unité de liaison d'une protéine cytotoxique hétéromère du type sauvage, pour la création d'une banque de clones de micro-organismes produisant des protéines mutantes dont la capacité à se fixer spécifiquement à une cellule cible et à la tuer est ensuite analysée.

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