Cytotoxic indeno and isoindoloisoquinolones

Details Cytotoxic indeno and isoindoloisoquinolones Cytotoxic indeno and isoindoloisoquinolones

A - Human Necessities

61

K

A61K 31/473 (2006.01) A61K 31/4745 (2006.01) C07D 221/18 (2006.01) C07D 471/12 (2006.01) C07D 491/02 (2006.01)

Patent

CA 2525099

The synthesis and biological activity of benzoisoindoloisoquinolone compounds are described. The synthesis and biological activity of C-11-substituted indenoisoquinolones are also described. Indenoisoquinolones substituted at C- 11 are prepared by McMurry reactions of 11-ketoindenoisoquinolones with aldehydes.

L'invention concerne la synthèse et l'activité biologique de composés de benzoisoindoloisoquinolone ainsi que la synthèse et l'activité biologique d'indénoisoquinolones C-11 substitués. Lesdits indénoisoquinolones C-11 substitués sont préparés à l'aide de réactions de McMurry entre des 11-cétoindénoisoquinolones et des aldéhydes.

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