C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/79 (2006.01) A61K 38/17 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 14/46 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2341037
The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and lipophilic amino acids as compared to the native lactoferrin sequence, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing such peptides, pharmaceutical compositions containing such peptides and use of the peptides as medicaments, particularly as antibacterials or anti-tumoural agents.
L'invention concerne un peptide modifié de lactoferrine présentant un caractère cytotoxique, une longueur de 7 à 25 acides aminés comportant trois ou plusieurs résidus cationiques, et possédant un ou plusieurs acides aminés supplémentaires volumineux et lipophiles par rapport à la séquence native de lactoferrine, ainsi que des esters, des amides, des sels et leurs dérivés cycliques, et des procédés servant à préparer ces peptides, des compositions pharmaceutiques contenant ces peptides et l'utilisation de ces derniers en tant que médicaments, en particulier, qu'agents antibactériens ou antitumoraux.
Rekdal Oystein
Sveinbjornsson Baldur
Svendsen John Sigurd
Vorland Lars
Alpharma As
Fetherstonhaugh & Co.
Lytix Biopharma As
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