Cytotoxic products formed by covalent bonding of a chain of...

Details Cytotoxic products formed by covalent bonding of a chain of... Cytotoxic products formed by covalent bonding of a chain of...

A - Human Necessities

61

K

167/139, 530/15.

A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/42 (2006.01)

Patent

CA 1188681

ABSTRACT OF THE DISCLOSURE Carcinostatic products are formed by coupling, by covalent bonding, the A chain of ricin with an antibody which is capable of selectively recognising a given antigen at the surface of cancerous cells. Such products can be made by the formation of a disulphide bridge between the free thiol group in the chain of ricin and an immunoglobulin or immunoglobulin fragment into which a thiol group or an activated disulphide group has been introduced. The A chain of ricin and the immunoglobulin are carefully purified before use.

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