Cytotoxic protein and utilization thereof

Details Cytotoxic protein and utilization thereof Cytotoxic protein and utilization thereof

C - Chemistry, Metallurgy

07

K

C07K 16/12 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 35/00 (2006.01) C07K 14/195 (2006.01) C07K 14/205 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2469154

This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced by Helicobacter pylori and the use. This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.

L'invention concerne une nouvelle protéine cytotoxique (toxine M: toxine dévastatrice de couche muqueuse) de Helicobacter pylori et son utilisation. Plus précisément, l'invention concerne une protéine cytotoxique (toxine M) produite par Helicabacter pylori, son peptide partiel et un agent antitumoral renfermant la protéine cytotoxique. Cette protéine cytotoxique peut être obtenue par la culture d'un transformant qui a été transformé par un vecteur de recombinaison contenant un ADN codant pour cette protéine. L'invention concerne enfin l'utilisation de la protéine cytotoxique.

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