Cytotoxic t-cell epitopes from chlamydia

Details Cytotoxic t-cell epitopes from chlamydia Cytotoxic t-cell epitopes from chlamydia

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/7088 (2006.01) A61K 39/118 (2006.01) C07K 14/295 (2006.01) C12Q 1/02 (2006.01) G01N 33/571 (2006.01)

Patent

CA 2475838

Cytotoxic T-cell epitopes from C.pneumoniae proteins have been empirically determined. The epitopes from corresponding C.trachomatis proteins have also been identified, and some of these are identical to those from C.pneumoniae. The empirical method showed that algorithmic prediction was inadequate. The epitopes are useful for immunisation and/or diagnosis.

Selon la présente invention, les épitopes de lymphocytes T cytotoxiques des protéines C.pneumoniae ont été déterminés de manière empirique. Les épitopes des protéines C.trachomatis correspondantes ont également été identifiés, certains de ces épitopes étant identiques à ceux de la protéine C.pneumoniae. Cette méthode empirique a démontré que la prédiction algorithmique est inadéquate. Ces épitopes sont utilisés pour l'immunisation et/ou le diagnostic.

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