Cytotoxic t-cell lymphocyte ("ctl") activity regulation by...

Details Cytotoxic t-cell lymphocyte ("ctl") activity regulation by... Cytotoxic t-cell lymphocyte ("ctl") activity regulation by...

C - Chemistry, Metallurgy

07

K

C07K 14/74 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/13 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) C07K 7/04 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2187193

Fragments from the polymorphic domains of Class I HLA antigen domains are used to modulate T-cell activity. The peptides are from the .alpha.l- or .alpha.2-domains, particularly of the HLA-A, and B antigens. The peptides may be conjugated to other compounds to be used in diagnosis and therapy. The peptides may block lysis, CTL proliferation or have other regulating effects.

On utilise des fragments provenant des domaines polymorphes des domaines d'antigènes HLA de classe I dans la modulation de l'activité des lymphocytes T. Les peptides proviennent des domaines .alpha.1 ou .alpha.2, notamment des antigènes HLA-A et B. On peut conjuguer les peptides avec d'autres composés en vue d'un usage diagnostique et thérapeutique. Les peptides peuvent bloquer la lyse et la prolifération de lymphocytes T cytotoxiques, ou présenter d'autres effets régulateurs.

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