C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2643555
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumour cells evidencing surface expression of CD59, and to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response The invention further relates to binding assays which utilize the CDMAB of the instant invention.
L'invention concerne le diagnostic et le traitement de maladies cancéreuses, notamment la médiation de cytotoxicité de cellules tumorales mettant en évidence l'expression superficielle de CD59, et l'utilisation d'anticorps modifiant les maladies cancéreuses (CDMAB), éventuellement en combinaison avec un ou plusieurs agents chimiothérapeutiques, en tant que moyens destinés à amorcer la réponse cytotoxique. L'invention concerne en outre des dosages de liaison qui utilisent ces CDMAB.
Cechetto Lisa M.
Dacruz Luis A. G.
Findlay Helen P.
Hahn Susan E.
Young David S. F.
Arius Research Inc.
F.hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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