A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 37/04 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2679050
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of primary and metastatic human tumor cells; and most particularly to the use of an isolated monoclonal antibody or cancerous disease modifying antibodies (CDMAB) thereof, optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response in such human tumors, e.g. any primary or metastatic tumor sites which arise from hepatocytes. The invention further relates to binding assays which utilize the CDMAB of the instant invention.
Cette invention concerne le diagnostic et le traitement de maladies cancéreuses et en particulier l'induction de cytotoxicité de cellules tumorales humaines primaires et métastatiques. L'invention concerne plus particulièrement l'utilisation d'un anticorps monoclonal isolé ou d'anticorps modifiant les maladies cancéreuses (CDMAB), éventuellement en association avec un ou plusieurs agents chimiothérapeutiques, comme moyen permettant d'amorcer la réponse cytotoxique dans de telles tumeurs humaines, par exemple tous sites tumoraux primaires ou métastatiques survenant à partir d'hépatocytes. L'invention concerne en outre des analyses de liaison utilisant ce CDMAB.
Fan Sheung Tat
Lee Terence Kin Wah
Poon Ronnie Tung Ping
Sayegh Daad
Young David S. F.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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