C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2643708
This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumour cells evidencing surface expression of CD44; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMAB of the instant invention.
L'invention concerne le diagnostic et le traitement de maladies cancéreuses, notamment, la médiation de cytotoxicité de cellules tumorales mettant en évidence l'expression superficielle de CD44; et plus particulièrement, l'utilisation d'anticorps (CDMAB) modifiant les maladies cancéreuses, éventuellement en combinaison avec un ou plusieurs agents chimiothérapeutiques, en tant que moyen d'amorcer la réponse cytotoxique. L'invention concerne également des dosages de liaison qui utilisent les CDMAB de l'invention.
Cechetto Lisa M.
Findlay Helen P.
Hahn Susan E.
Mcconkey Fortunata
Young David S. F.
Arius Research Inc.
F.hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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