C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2696027
This invention relates to the staging, diagnosis and treatment of cancerous diseases (both primary tumours and tumour metastases), particularly to the mediation of cytotoxicity of tumour cells evidencing surface expression of CD9, and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB/chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays, which utilize the CDMAB of the instant invention. The anti-cancer antibodies can be conjugated to toxms, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
Cette invention porte sur la stadification, le diagnostic et le traitement de maladies cancéreuses (à la fois de tumeurs primaires et de métastases de tumeur), en particulier sur la médiation de la cytotoxicité de cellules tumorales mettant en évidence l'expression de surface de CD9 et, de la façon la plus spécifique, sur l'utilisation d'anticorps modifiant une maladie cancéreuse (CDMAB), en combinaison facultative avec un ou plusieurs agents CDMAB/chimiothérapeutiques comme moyens d'initiation de la réponse cytotoxique. L'invention porte en outre sur des dosages de liaison qui utilisent le CDMAB de la présente invention. Les anticorps anti-cancer peuvent être conjugués à des toxines, des enzymes, des composés radioactifs, des cytokines, des interférons, des fractions cibles ou reporters et des cellules hématogènes.
Cechetto Lisa M.
Ferry Alison L.
Findlay Helen P.
Hahn Susan E.
Young David S. F.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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