C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 315/00 (2006.01) A61K 31/335 (2006.01)
Patent
CA 2556550
A compound or groups of compounds, present in an active principle, derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
L'invention concerne un composé ou un groupe de composés présents dans un principe actif, dérivés de tuniciers appartenant à l'espèce Synoicum adareanum, ainsi que des compositions pharmaceutiques contenant ces composés. Les extraits de tuniciers présentent une toxicité sélective contre une pluralité de lignées de cellules cancéreuses différentes du panel de lignées cellulaires NCI 60. Ces composés permettent un traitement efficace des cancers, en particulier des mélanomes malins, des cancers du côlon et des cancers rénaux.
Amsler Charles D.
Baker Bill J.
Diyabalanage Thushara
Mcclintock James B.
Mbm Intellectual Property Law Llp
The Uab Research Foundation
University Of South Florida
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