Cytotoxin with a subtilase domain

Details Cytotoxin with a subtilase domain Cytotoxin with a subtilase domain

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) A61K 39/02 (2006.01) C07K 14/195 (2006.01) C07K 16/12 (2006.01) C07K 16/40 (2006.01) C12N 9/52 (2006.01) C12N 15/31 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2465009

A member of a new class of bacterial toxin has been isolated and characterised. The bacterial toxin is of the AB5 type and is characterised in that it has a subtilase domain. It is cytotoxic to Vero cells, and toxicity in vivo in mice occurs in a number of different sites. Mutation of the serine active residue results in greater than 99% reduction in activity. The protein has been purified and antibodies have been prepared for both the A subunit and B subunits, and ELISA detection methods have been developed. The nucleic acid sequence has been determined and primers specific for the toxin have been used for a preliminary screen of a range of patient samples to ascertain the extent to which the toxin is present.

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