D-enantiomer of dfmo and methods of use therefor

Details D-enantiomer of dfmo and methods of use therefor D-enantiomer of dfmo and methods of use therefor

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2402122

The present invention concerns a method for preventing and/or treating cancer in a patient comprising administering an effective amount of substantially purified D enantiomer of difluoromethylornithine (D-DFMO) or an analog of D- DFMO to the patient. D-DFMO or an analog thereof is administered at a dose of about 0.05 to about 20.0 gm/M2/day. D-DFMO or an analog thereof may be administered more than once for the treatment and/or prevention of cancer. Methods of administration as well as compositions and formulations of substantially purified D-DFMO and analogs of D-DFMO are described.

L'invention concerne un procédé permettant de prévenir et/ou de traiter le cancer chez un patient, qui consiste à lui administrer une dose efficace d'un énantiomère en D sensiblement pur de difluorométhyl-ornithine (D-DFMO) ou analogue. D-DFMO ou analogue est administré en dose d'environ 0,05 à 20,0 gm/M?2¿/jour. D-DFMO ou analogue peut être administré plusieurs fois pour le traitement et/ou la prévention du cancer. L'invention concerne également des procédés d'administration ainsi que les compositions et les formules de D-DFMO et analogues sensiblement purs.

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