D-glucopyranosyl phenyl-substituted cyclene, medicaments...

Details D-glucopyranosyl phenyl-substituted cyclene, medicaments... D-glucopyranosyl phenyl-substituted cyclene, medicaments...

C - Chemistry, Metallurgy

07

D

C07D 309/12 (2006.01) A61K 31/351 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2574451

The invention relates to D-glucopyranosyl phenyl-substituted cyclene of general formula (I), in which: radicals R1 to R6, Z, Cy as well as R7a, R7b, R7c, R7d are defined as in Claim 1. The inventive compounds have an inhibitory effect upon the sodium-dependent glucose co-transporter SGLT. The invention also relates to medicaments for treating metabolic diseases.

L'invention concerne des cyclènes substitués par D-glucopyranosyle-phényle de formule (I) dans laquelle les restes R1 à R6, Z, Cy, ainsi que R7, R7, R7, R7 sont définis comme dans la revendication 1. Lesdits composés présentent une action inhibitrice sur les glucose-cotransporteurs sodium-dépendants SGLT. L'invention concerne également des médicaments utilisés pour traiter des maladies métaboliques.

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