D-homo oxasteroids

Details D-homo oxasteroids D-homo oxasteroids

C - Chemistry, Metallurgy

07

J

260/3

C07J 73/00 (2006.01)

Patent

CA 1113925

ABSTRACT D-HOMO OXASTEROIDS Novel steroids, which can be used as anti- inflammatory agents, have the formula Image or the 1,2-dehydro derivative thereof; wherein R1 is hydrogen, alkyl-?-O-, aryl-?-0-, halogen or hydroxy; R2 is hydrogen or alkyl; R3 is alkyl; R4 is carbonyl, .beta.-hydroxymethylene, .beta.-chloromethylene or .beta.-bromomethyl- ene; R5 is hydrogen, fluorine, chlorine or bromine; R6 is hydrogen, fluorine or methyl; and R7 is hydrogen, chlorine or bromine; with the proviso that when R1 is hydroxy, R2 is alkyl; and with the further proviso that when R2 is alkyl, it is the same alkyl group as R3; wherein aryl is phenyl or phenyl substituted with one or two alkyl, alkoxy or halogen groups; and alkyl and alkoxy are groups having 1 to 10 carbon atoms.

306430

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