C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/4
C07J 5/00 (2006.01) C07J 7/00 (2006.01) C07J 31/00 (2006.01) C07J 63/00 (2006.01)
Patent
CA 1114364
ABSTRACT The present invention relates to a process for the manufacture of novel D-homosteroids of the general formula (I) Image wherein R6 represents a hydrogen, chlorine or fluorine atom or a methyl group, X represents a .beta.-hydroxymethylene or carbonyl group, R17a represents a hydroxy or acyloxy group and R21 represents a hydrogen, chlorine or fluorine atom or a hydroxy or acyloxy group or a sulphate or phosphate residue, and wherein the broken line in the 1,2-position denotes an optional carbon-carbon bond, and of salts thereof, which process comprises cleaving off hydrogen bromide from a compound of the general formula Image (II) wherein R6, X, R17a, R21 and the broken line in the 1,2-position have the significance given above, and, if desired, saponifying an acyloxy group, esterifying a hydroxy group present in the 17a- and/or 21-position, oxidising an 11-hydroxy group, dehydrogenating a 1,2-ethylene group and/ or converting a compound of formula I obtained into a salt. These compounds have hormonal activity.
301515
Alig Leo
Furst Andor
Kerb Ulrich
Muller Marcel
Wiechert Rudolf
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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