D-homosteroids

Details D-homosteroids D-homosteroids

C - Chemistry, Metallurgy

07

J

260/4, 195/86

C07J 63/00 (2006.01) C12P 33/02 (2006.01) C12P 33/08 (2006.01)

Patent

CA 1138857

ABSTRACT Novel D-homosteroids with endocrinal, especially anti- inflammatory, activity and having the formula Image I wherein R6 represents a hydrogen, fluorine or chlorine atom or a methyl group; R9 represents a hydrogen, fluorine, chlorine of bromino atom; R11 represents an oxo or (.alpha.-H,.beta.-OH) group when R9 represents a hydrogen atom or an oxo, (.alpha.-H,.beta.-OH), (.alpha.-H,.beta.-fluoro) or (.alpha.-H,.beta.-chloro) group when R9 represents a fluorine, chlorine or bromine atom, with the proviso that, in the case of 9,11-dihalo compounds, the atomic number of the halogen atom in the 9-position is not less than the atomic number of the halogen atom in the 11- -position; R17a represents an acyloxy group and R20 represents a lower alkyl or halo-(lower alkyl) group and wherein the broken line in the 1,2-position denotes an optional carbon-carbon bond, a process for their manufacture and medicaments containing said D-homosteroids.

341528

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