D-mannitol derivatives as hiv aspartyl protease inhibitors

Details D-mannitol derivatives as hiv aspartyl protease inhibitors D-mannitol derivatives as hiv aspartyl protease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 43/178 (2006.01) A61K 31/075 (2006.01) A61P 31/18 (2006.01) C07C 43/13 (2006.01) C07C 45/44 (2006.01) C07C 47/575 (2006.01) C07C 69/76 (2006.01) C07C 205/37 (2006.01) C07C 217/48 (2006.01) C07C 217/76 (2006.01) C07C 235/46 (2006.01) C07C 255/54 (2006.01) C07C 255/57 (2006.01) C07C 271/28 (2006.01) C07C 323/12 (2006.01) C07C 329/16 (2006.01) C07D 213/30 (2006.01) C07D 333/16 (2006.01)

Patent

CA 2372672

A D-mannitol derivative selected from the group consisting of a compound of formula (I) pharmaceutically acceptable derivatives thereof and where applicable or appropriate pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are the same or different and may, for example, each independently be selected from among alkyl and aryl (i.e. aromatic including aromatic like) groups. The D-mannitol derivatives may be used as HIV aspartyl protease inhibitors.

L'invention concerne un dérivé du D-mannitol sélectionné dans le groupe constitué d'un composé de formule (I), de ses dérivés pharmaceutiquement acceptables et de ses sels pharmaceutiquement acceptables lorsque cela est approprié ou applicable. Dans la formule, R¿1?, R¿2?, R¿3? et R¿4? sont identiques ou différents et peuvent notamment être choisis indépendamment dans des groupes alkyle et aryle (p.ex aromatique et analogues). Les dérivés de D-mannitol peuvent être utilisés en tant qu'inhibiteurs de l'aspartyle protéase du VIH.

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