C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C12N 1/21 (2006.01) C12N 9/18 (2006.01) C12N 15/70 (2006.01) C12P 17/04 (2006.01) C12P 21/02 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2204743
A novel enzyme which is useful in the optical resolution of D,L-pantolactone via D-selective asymmetric hydrolysis and a gene encoding the the same are provided. The invention discloses the gene coding for a natural D-pantolactone hydrolase (for example, one originating in Fusarium oxysporum) or proteins having an activity substantially equivalent thereto; host cells transformed with DNA containing a nucleotide sequence coding for said protein, processes for producing said protein via using said host cells and uses of said proteins and host cells.
Nouvelle enzyme utile dans la résolution optique de D,L-pantolactone via l'hydrolyse asymétrique à sélection D et gène codant ladite enzyme. La présente invention concerne un gène codant une D-pantolactone hydrolase naturelle (par exemple, une D-pantolactone hydrolase tirée de Fusarium oxysporum) ou une protéine ayant pratiquement la même activité que ladite enzyme, des cellules hôtes transformées par un ADN contenant une séquence de base qui code la protéine susmentionnée, un procédé de production de ladite protéine à l'aide des cellules hôtes et les utilisations de ladite protéine et des cellules hôtes.
Kobayashi Michihiko
Sakamoto Keiji
Shimizu Sakayu
Yamada Hideaki
Daiichi Fine Chemical Co. Ltd.
Fetherstonhaugh & Co.
Fuji Yakuhin Kogyo Kabushiki Kaisha
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