D-phenylalanyl-l-propyl-l-arginine aldehyde sulfate and...

Details D-phenylalanyl-l-propyl-l-arginine aldehyde sulfate and... D-phenylalanyl-l-propyl-l-arginine aldehyde sulfate and...

C - Chemistry, Metallurgy

07

K

530/5.08

C07K 5/065 (2006.01)

Patent

CA 1182111

A B S T R A C T O F T H E D I S C L O S U R E The invention relates to D-phenylalanyl-L- -prolyl-L-arginine aldehyde sulfate, highly stable in aqueous solution, and to a process for preparing it from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or NG-carboxy derivative con- taining an acid-sensitive protecting group at its amino terminal,wherein the acid sensitive amino terminal protecting group or optionally the NG-carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts end the resulting free tripeptide aldehyde sulfate is isolated, The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anti- coagulant activity.

393981

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