Dalbavancin compositions for treatment of bacterial infections

Details Dalbavancin compositions for treatment of bacterial infections Dalbavancin compositions for treatment of bacterial infections

A - Human Necessities

61

K

A61K 38/16 (2006.01) C07K 9/00 (2006.01)

Patent

CA 2564112

The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A0, A1, B1, B2, CO, C1, isoB0, and MAG, in the presence of low level solvent. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimens include multiple dose administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection. Dosing regimens for renal patients are also included.

L'invention concerne des méthodes et des compositions pour le traitement d'infections bactériennes. La composition de l'invention peut être une combinaison de facteurs, comprenant A0, A1, B1, B2, CO, C1, isoB0, et MAG, en présence d'un faible taux de solvant. Les méthodes de l'invention consistent à administrer des préparations de dalbavancin pour le traitement d'une infection bactérienne, notamment une infection bactérienne à gram positif de la peau et du tissu mou. Des schémas posologiques comprennent l'administration de doses multiples de dalbavancin, qui reste souvent à des niveaux thérapeutiques dans le courant sanguin pendant au moins une semaine, ce qui confère une action thérapeutiques prolongée contre une infection bactérienne. Des schémas posologiques pour les patients souffrant d'une affection rénale sont également décrits.

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