C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/08 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) A61P 31/18 (2006.01) A61P 37/04 (2006.01) C07K 16/00 (2006.01) C07K 16/12 (2006.01) C07K 16/14 (2006.01) C07K 16/20 (2006.01)
Patent
CA 2623540
The present invention provides an antibody specifically directed to an epitope that is not immunodominant in an antigen of a pathogenic organism, produced by immunizing a mammal with vaccine that can be administered to a mammal to cause immunoprotection in the mammal against a pathogenic organism that has an immunodominant epitope. The vaccine includes a modified form of the antigen in which the immunodominant epitope is located. In this modified form, the immunodominant epitope is immunodampened by any of a number of techniques. Examples of immunodampening techniques include addition of N-linked glycosylation sites, change of the net charge of the epitope, and substitution with a tolerated sequence. The vaccine also includes a pharmacologically acceptable carrier.
Garrity Robert R.
Goudsmit Jaap
Nara Peter L.
Depar Tment Of Health And Human Services The Government Of The United States Represented By The Secretary
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Fetherstonhaugh & Co.
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