Dapd combination therapy with inosine monophosphate...

Details Dapd combination therapy with inosine monophosphate... Dapd combination therapy with inosine monophosphate...

A - Human Necessities

61

K

A61K 31/7076 (2006.01) A61K 31/365 (2006.01) A61K 31/70 (2006.01) A61K 31/7056 (2006.01) A61K 31/708 (2006.01) A61K 45/06 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2432287

It has been unexpectedly found that a drug resistant strain of HIV exhibits the behavior of drug-naïve virus when given the combination of a .beta.-D-1,3- dioxolanyl nucleoside and an IMPDH inhibitor. In one nonlimiting embodiment, the HIV strain is resistant to a .beta.-D-1,3-dioxolanyl nucleoside.

On a découvert inopinément qu'une souche de VIH résistante aux médicaments présentait le comportement d'un virus naïf par rapport aux médicaments quand on lui administre la combinaison d'un nucléoside de .beta.-D-1,3-dioxolanyle et d'un inhibiteur de IMPDH. Dans un mode de réalisation non restrictif, la souche de VIH est résistante à un nucléoside de .beta.-D-1,3-dioxolanyle.

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