Darusentan oral dosage form

Details Darusentan oral dosage form Darusentan oral dosage form

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 31/505 (2006.01)

Patent

CA 2668724

A solid discrete orally deliverable pharmaceutical dosage form comprises darusentan and one or more pharmaceutically acceptable excipients; wherein (a) the darusentan is in solid particulate form having a mean particle size of about 5 to about 200 µm and is present in the dosage form in an amount of about 1 to about 600 mg; and (b) the dosage form exhibits at least about 90% dissolution of the darusentan in 30 minutes in a standard in vitro dissolution test. A method for lowering blood pressure, for example in a patient having resistant hypertension, comprises administering such a dosage form once daily to the patient.

L'invention concerne une forme posologique pharmaceutique solide et discrète à administration orale qui comprend du darusentan et un ou plusieurs excipients pharmaceutiquement acceptable. Dans cette forme de dosage: (a) le darusentan est sous forme de particules solides à dimension de particule moyenne comprise entre environ 5 à 200 µm et est présent dans la forme posologique en quantité comprise entre environ 1 et 600 mg; et (b) la forme posologique présente au moins environ 90% de dissolution du darusentan en 30 minutes dans un test de dissolution in vitro standard. L'invention concerne également un procédé destiné à réduire la pression sanguine, par exemple chez un patient souffrant d'hypertension résistante, qui consiste à administrer quotidiennement une telle forme posologique au patient.

Affiliated with

Also associated with

Rating

Darusentan oral dosage form does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Darusentan oral dosage form, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Darusentan oral dosage form will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1662057